Department of Biology
University of Rochester
Biology and genetics of PrP prion strains.
Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing.
Auophagic Punctum: Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.
Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.
Ion-current-based temporal proteomic profiling of influenza-A-virus-infected mouse lungs revealed underlying mechanisms of altered integrity of the lung microvascular barrier.
Analysis of proteome dynamics in mice by isotopic labeling.
Successes and challenges in phenotype-based lead discovery for prion diseases.
Kinetics of precursor labeling in SILAC experiments.
Convergent replication of mouse synthetic prion strains.
Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells.
Strain Specificity and Drug Resistance in Anti- Prion Therapy.
Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling.
Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.
Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.
A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling.
Conformational transformation and selection of synthetic prion strains.
A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.
Analysis of proteome dynamics in the mouse brain.
Chemical induction of misfolded prion protein conformers in cell culture.
Discovery of 2-aminothiazoles as potent antiprion compounds.
Continuous quinacrine treatment results in the formation of drug-resistant prions.
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.
Cell division modulates prion accumulation in cultured cells.
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.
Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.
Global analysis of protein expression in yeast.
A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.
Quantitative protein stability measurement in vivo.
A quantitative, high-throughput screen for protein stability.
Folding kinetics of a fluorescent variant of monomeric lambda repressor.