Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome.

Walker EJ, Bettinger JQ, Welle KA, Hryhorenko JR, Ghaemmaghami S

Proc Natl Acad Sci U S A. 2019 Mar 7.

bioRxiv 467290; doi: https://doi.org/10.1101/467290. Nov 2018.

JNK modifies neuronal metabolism to promote proteostasisand longevity.

Lifen Wang, Sonnet S. Davis, Martin Borch Jensen, Imilce A. Rodriguez‐Fernandez, Cagsar Apaydin, Gabor Juhasz, Bradford W. Gibson, Birgit Schilling, Arvind Ramanathan, Sina Ghaemmaghami, Heinrich Jasper

Aging Cell. Feb 2019.


Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos.

Johnson MR, Stephenson RA, Ghaemmaghami S, Welte MA.

Elife. 2018 Jul 25;7. pii: e36021.

Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice.

Popa-Wagner A, Sandu RE, Cristin C, Uzoni A, Welle KA, Hryhorenko JR, Ghaemmaghami S.

Front Aging Neurosci. 2018 Feb 16;10:32.

Cross-species comparison of proteome turnover kinetics.

Swovick K, Welle KA, Hryhorenko J, Seluanov A, Gorbunova V, Ghaemmaghami S.

Mol Cell Proteomics. 2018 Jan 10. pii: mcp.RA117.000574.


Proteome-wide modulation of degradation dynamics in response to growth arrest.

Zhang T, Wolfe C, Pierle A, Welle KA, Hryhorenko JR, Ghaemmaghami S.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10329-E10338.

Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS.

The Biochemical journal. 2017 Aug 10;474(16):2829-2839.


Biology and genetics of PrP prion strains.

Ghaemmaghami S.

Cold Spring Harb Perspect Med. 2016 doi: 10.1101/cshperspect.a026922

Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing.

Welle KA, Zhang T, Hyrohorenko JR, Shen S, Qu J, Ghaemmaghami S.

Mol Cell Proteomics. 2016 Dec;15(12):3551-3563.

Autophagic Punctum: Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.

Zhang T, Ghaemmaghami S.

Autophagy. 2016 Aug 2;12(8):1411-2.

Global analysis of cellular protein flux quantifies the selectivity of basal autophagy.

Zhang T, Shen S, Qu J, Ghaemmaghami S.

Cell Rep. 2016 Mar 15;14(10):2426-39.

Ion-current-based temporal proteomic profiling of influenza-A-virus-infected mouse lungs revealed underlying mechanisms of altered integrity of the lung microvascular barrier.

Shen S, Li J, Hilchey S, Shen X, Tu C, Qiu X, Ng A, Ghaemmaghami S, Wu H, Zand MS, Qu J.

J Proteome Res. 2016 Feb 5;15(2):540-53


Analysis of proteome dynamics in mice by isotopic labeling.

Price JC, Ghaemmaghami S.

Methods Mol Biol. 2014;1156:111-31.

Successes and challenges in phenotype-based lead discovery for prion diseases.

Ghaemmaghami S, Russo M, Renslo AR.

J Med Chem. 2014 Aug 28;57(16):6919-29.

Kinetics of precursor labeling in SILAC experiments.

Zhang T, Nouri E, Li J, Price JC, Hellerstein M, Qu J, Ghaemmaghami S.

Anal Chem. 2014 Nov 18;86(22):11334-41.


Convergent replication of mouse synthetic prion strains.

Ghaemmaghami S, Colby DW, Nguyen HO, Hayashi S, Oehler A, DeArmond SJ, Prusiner SB.

Am J Pathol. 2013 Mar;182(3):866-74.

Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells.

Silber BM, Gever JL, Li Z, Gallardo-Godoy A, Renslo AR, Widjaja K, Irwin JJ, Rao S, Jacobson MP, Ghaemmaghami S, Prusiner SB.

Bioorgan Med Chem 2013 Dec 15;21(24):7999-8012.

Strain Specificity and Drug Resistance in Anti- Prion Therapy.

Miller-Vedam L, Ghaemmaghami S.

Cur Top Med Chem. 2013;13(19):2397-406.


Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling.

Guan S, Price JC, Ghaemmaghami S, Prusiner SB, Burlingame AL.

Anal Chem. 2012 May 1;84(9):4014-21.

Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter.

Ahn M, Ghaemmaghami S, Huang Y, Phuan PW, May BC, Giles K, DeArmond SJ, Prusiner SB.

PLoS One. 2012;7(7):e39112.

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.

Friberg KN, Hung G, Wancewicz E, Giles K, Black C, Freier S, Bennett F, DeArmond SJ, Freyman Y, Lessard P, Ghaemmaghami S, Prusiner SB.

Mol Ther Nucleic Acids. 2012 February; 1(2): e9.

Pre 2012

A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling.

Guan S, Price JC, Prusiner SB, Ghaemmaghami S, Burlingame AL.

Mol Cell Proteomics. 2011 Dec;10(12):M111.010728.

Conformational transformation and selection of synthetic prion strains.

Ghaemmaghami S, Watts JC, Nguyen HO, Hayashi S, DeArmond SJ, Prusiner SB.

J Mol Biol. 2011 Oct 28;413(3):527-42.

A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets.

Poncet-Montange G, St Martin SJ, Bogatova OV, Prusiner SB, Shoichet BK, Ghaemmaghami S.

J Biol Chem. 2011 Aug 5;286(31):27718-28.

Analysis of proteome dynamics in the mouse brain.

Price JC, Guan S, Burlingame A, Prusiner SB, Ghaemmaghami S.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14508-13.

Chemical induction of misfolded prion protein conformers in cell culture.

Ghaemmaghami S, Ullman J, Ahn M, St Martin S, Prusiner SB.

J Biol Chem. 2010 Apr 2;285(14):10415-23.

Discovery of 2-aminothiazoles as potent antiprion compounds.

Ghaemmaghami S, May BC, Renslo AR, Prusiner SB.

J Virol. 2010 Apr;84(7):3408-12.

Continuous quinacrine treatment results in the formation of drug-resistant prions.

Ghaemmaghami S, Ahn M, Lessard P, Giles K, Legname G, DeArmond SJ, Prusiner SB.

PLoS Pathog. 2009 Nov;5(11):e1000673.

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.

Ingolia NT, Ghaemmaghami S, Newman JR, Weissman JS.

Science. 2009 Apr 10;324(5924):218-23.

Cell division modulates prion accumulation in cultured cells.

Ghaemmaghami S, Phuan PW, Perkins B, Ullman J, May BC, Cohen FE, Prusiner SB.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17971-6.

Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.

Newman JR, Ghaemmaghami S, Ihmels J, Breslow DK, Noble M, DeRisi JL, Weissman JS.

Nature. 2006 Jun 15;441(7095):840-6.

Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.

Howson R, Huh WK, Ghaemmaghami S, Falvo JV, Bower K, Belle A, Dephoure N, Wykoff DD, Weissman JS, O'Shea EK.

Comp Funct Genomics. 2005;6(1-2):2-16.

Global analysis of protein expression in yeast.

Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS.

Nature. 2003 Oct 16;425(6959):737-41.

A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution.

Powell KD, Ghaemmaghami S, Wang MZ, Ma L, Oas TG, Fitzgerald MC.

J Am Chem Soc. 2002 Sep 4;124(35):10256-7.

Quantitative protein stability measurement in vivo.

Ghaemmaghami S, Oas TG.

Nat Struct Biol. 2001 Oct;8(10):879-82.

A quantitative, high-throughput screen for protein stability.

Ghaemmaghami S, Fitzgerald MC, Oas TG.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8296-301.

Folding kinetics of a fluorescent variant of monomeric lambda repressor.

Ghaemmaghami S, Word JM, Burton RE, Richardson JS, Oas TG.

Biochemistry. 1998 Jun 23;37(25):9179-85.

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