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Ghaemmaghami Lab Department of Biology University of Rochester |
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Ghaemmaghami Lab Department of Biology University of Rochester |
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2024
Enzymatic synthesis of isotopically labeled hydrogen peroxide for mass spectrometry-based applications
Proteome birthdating reveals age-selectivity of protein ubiquitination
Formylation facilitates the reduction of oxidized initiator methionines
Methionine Alkylation as an Approach to Quantify Methionine Oxidation Using Mass Spectrometry
Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome
2023
In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response
Folding stabilities of ribosome-bound nascent polypeptides probed by mass spectrometry
Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes
2022
Accurate proteome-wide measurement of methionine oxidation in aging mouse brains
Protein folding stabilities are a major determinant of oxidation rates for buried methionine residues
2021
Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization
MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling
2020
Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands
Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain
Proc Natl Acad Sci U S A. 2020 Nov 3.
bioRxiv 2019.12.24.885962; doi: https://doi.org/10.1101/2019.12.24.885962
Methionine oxidation within the prion protein
Quantitative analysis of in vivo methionine oxidation of the human proteome
bioRxiv 714089; doi: https://doi.org/10.1101/714089 Jul 2019.
Global analysis of protein degradation in prion infected cells
Sci Rep. 2020;10(1):10800. 2020 Jul 1.
bioRxiv 712927; doi: https://doi.org/10.1101/712927 Jul 2019.
2019
JNK modifies neuronal metabolism to promote proteostasisand longevity
Global analysis of methionine oxidation provides a census of folding stabilities for the human proteome
Proc Natl Acad Sci U S A. 2019 Mar 7.
bioRxiv 467290; doi: https://doi.org/10.1101/467290. Nov 2018.
2018
Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos
Increased Degradation Rates in the Components of the Mitochondrial Oxidative Phosphorylation Chain in the Cerebellum of Old Mice
Cross-species comparison of proteome turnover kinetics
2017
Proteome-wide modulation of degradation dynamics in response to growth arrest
Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10329-E10338.
Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation
2016
Biology and genetics of PrP prion strains
Cold Spring Harb Perspect Med. 2016 doi: 10.1101/cshperspect.a026922
Time-resolved analysis of proteome dynamics by TMT-SILAC hyperplexing
Autophagic Punctum: Global analysis of cellular protein flux quantifies the selectivity of basal autophagy
Global analysis of cellular protein flux quantifies the selectivity of basal autophagy
Ion-current-based temporal proteomic profiling of influenza-A-virus-infected mouse lungs revealed underlying mechanisms of altered integrity of the lung microvascular barrier
Pre 2016
Analysis of proteome dynamics in mice by isotopic labeling.
Successes and challenges in phenotype-based lead discovery for prion diseases
Kinetics of precursor labeling in SILAC experiments.
Convergent replication of mouse synthetic prion strains
Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells
Strain Specificity and Drug Resistance in Anti- Prion Therapy
Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling
Pharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporter
Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling
Conformational transformation and selection of synthetic prion strains
A survey of antiprion compounds reveals the prevalence of non-PrP molecular targets
Analysis of proteome dynamics in the mouse brain
Chemical induction of misfolded prion protein conformers in cell culture
Discovery of 2-aminothiazoles as potent antiprion compounds
Continuous quinacrine treatment results in the formation of drug-resistant prions
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
Cell division modulates prion accumulation in cultured cells
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains
Global analysis of protein expression in yeast
A general mass spectrometry-based assay for the quantitation of protein-ligand binding interactions in solution
Quantitative protein stability measurement in vivo
A quantitative, high-throughput screen for protein stability
Folding kinetics of a fluorescent variant of monomeric lambda repressor